abstract：:The protective role of exogenous melatonin on U-induced nephrotoxicity was investigated in rats. Animals were given single doses of uranyl acetate dihydrate (UAD) at 5 mg/kg (subcutaneous), melatonin at 10 or 20 mg/kg (intraperitoneal), and UAD (5 mg/kg) plus melatonin (10 or 20 mg/kg), or vehicle (control group). In ...

journal_title：Journal of pineal research

authors： Bellés M,Linares V,Luisa Albina M,Sirvent J,Sánchez DJ,Domingo JL

更新日期：2007-08-01 00:00:00

abstract：:GPR50 is an orphan seven transmembrane protein related to the melatonin receptor subfamily comprising MT(1) and MT(2) receptors. In the absence of any known ligand for GPR50, other tools are critical for the characterization of this protein. Here, we describe the generation, purification and characterization of the fi...

journal_title：Journal of pineal research

authors： Hamouda HO,Chen P,Levoye A,Sözer-Topçular N,Daulat AM,Guillaume JL,Ravid R,Savaskan E,Ferry G,Boutin JA,Delagrange P,Jockers R,Maurice P

更新日期：2007-08-01 00:00:00

abstract：:The presence of melatonin and the enzymes (transcripts and activities) involved in its synthesis, i.e. arylalkylamine N-acetyltransferase (AA-NAT) and hydroxyindole-O-methyltransferase (HIOMT), was investigated in the eggs and early embryos of Japanese quail at Hamburger-Hamilton stages 1-10. Melatonin was present in ...

journal_title：Journal of pineal research

authors： Olszańska B,Majewski P,Lewczuk B,Stepińska U

更新日期：2007-04-01 00:00:00

abstract：:Melatonin is known to regulate a variety of physiological processes including control of circadian rhythms, regulation of seasonal reproductive function, regulation of body temperature, and so forth. Accumulating evidence from in vitro and in vivo experiments using rodent and chicken has also suggested that melatonin ...

journal_title：Journal of pineal research

authors： Satomura K,Tobiume S,Tokuyama R,Yamasaki Y,Kudoh K,Maeda E,Nagayama M

更新日期：2007-04-01 00:00:00

abstract：:This study examined the factors that may be involved in altering the function of pineal gland in hypoxic conditions. Adult Wistar rats were subjected to hypoxia and the pineal gland was examined for the mRNA and protein expression of hypoxia-inducible factor-1alpha (HIF-1alpha), vascular endothelial growth factor (VEG...

journal_title：Journal of pineal research

authors： Kaur C,Sivakumar V,Lu J,Ling EA

更新日期：2007-04-01 00:00:00

abstract：:Earlier studies showed that melatonin reduced the growth of 17-beta-estradiol (E(2))-induced rat pituitary prolactin-secreting tumor (prolactinoma) in vivo. The mechanisms of melatonin's inhibitory action on the prolactin-secreting tumor were further explored by investigating the in vitro effects of melatonin on the g...

journal_title：Journal of pineal research

authors： Yang QH,Xu JN,Xu RK,Pang SF

更新日期：2007-03-01 00:00:00

abstract：:Melatonin, a potent antioxidant, has shown to be beneficial in murine Venezuelan equine encephalomyelitis (VEE) virus infection. In addition, melatonin can induces the production of interleukin-1 beta (IL-1beta), a cytokine capable of inducing increased expression of inducible nitric oxide synthase; the activity of th...

journal_title：Journal of pineal research

authors： Valero N,MarinaEspina L,Bonilla E,Mosquera J

更新日期：2007-03-01 00:00:00

abstract：:Aging is accompanied by changes in the morphology and physiology of organs and tissues, such as the liver. This process might be due to the accumulation of oxidative damage induced by reactive oxygen (ROS) and reactive nitrogen species (RNS). Hepatocytes are very rich in mitochondria and have a high respiratory rate, ...

journal_title：Journal of pineal research

authors： Kireev RA,Tresguerres AC,Castillo C,Salazar V,Ariznavarreta C,Vara E,Tresguerres JA

更新日期：2007-01-01 00:00:00

abstract：:Melatonin is a highly effective treatment in different animal models of excitotoxicity or ischemia/reperfusion injury. Due to a lack of patentability, commercial sponsors are not interested in funding clinical evaluations of melatonin. Investigators may initiate small-scale clinical evaluation, and intravenous (i.v.) ...

journal_title：Journal of pineal research

authors： Cheung RT,Tipoe GL,Tam S,Ma ES,Zou LY,Chan PS

更新日期：2006-11-01 00:00:00

abstract：:The association of seasonal changes in health and disease has been known for centuries. The prevalence of psychopathological symptoms with seasonal fluctuations and the use of melatonin as a biological marker of circadian and circannual rhythms is well documented. The aim of this work was to study the variability of m...

journal_title：Journal of pineal research

authors： Morera AL,Abreu P

更新日期：2006-10-01 00:00:00

abstract：:The rod outer segment (ROSg) membranes are essentially lipoprotein complexes. Rhodopsin, the major integral protein of ROSg, is surrounded by phospholipids highly enriched in docosahexaenoic acid (22:6 n3). This fluid environment plays an important role for conformational changes after photo-activation. Thus, ROSg mem...

journal_title：Journal of pineal research

authors： Guajardo MH,Terrasa AM,Catalá A

更新日期：2006-10-01 00:00:00

abstract：:It has been suggested that oxidative stress is a feature of aging. The goal of the present study was to assess the oxidant effects related to aging and the protective role of exogenous melatonin in senescence-accelerated mice (SAMP8). Two groups of SAMP8 mice (males and females) were compared with their respective con...

journal_title：Journal of pineal research

authors： Nogués MR,Giralt M,Romeu M,Mulero M,Sánchez-Martos V,Rodríguez E,Acuña-Castroviejo D,Mallol J

更新日期：2006-09-01 00:00:00

abstract：:The purpose of this study was to determine and compare the light sensitivity of two commercially important, phylogenetically different teleost species in terms of melatonin production. Three series of experiments were performed on both Atlantic salmon and European sea bass. First, a range of light intensities were tes...

journal_title：Journal of pineal research

authors： Migaud H,Taylor JF,Taranger GL,Davie A,Cerdá-Reverter JM,Carrillo M,Hansen T,Bromage NR

更新日期：2006-08-01 00:00:00

abstract：:Melatonin is a powerful antioxidant and free radical scavenger. A large body of in vivo and in vitro evidence shows that melatonin effectively inhibits membrane lipid peroxidation; this damage was based on the measurement of malondialdehyde and/or 4-hydroxynonenal levels. In the current study, for the first time using...

journal_title：Journal of pineal research

authors： Zhang L,Wei W,Xu J,Min F,Wang L,Wang X,Cao S,Tan DX,Qi W,Reiter RJ

更新日期：2006-05-01 00:00:00

abstract：:Rabbitfish are a restricted lunar-synchronized spawner that spawns around a species-specific lunar phase. It is not known how the fish perceive changes in cues from the moon. One possible explanation is that rabbitfish utilize changes in moonlight intensity to establish synchrony. The purpose of the present study was ...

journal_title：Journal of pineal research

authors： Takemura A,Ueda S,Hiyakawa N,Nikaido Y

更新日期：2006-04-01 00:00:00

abstract：:There are functional inter-relationships between the beta cells of the endocrine pancreas and the pineal gland, where the synchronizing circadian molecule melatonin originates. The aim of this study was to elucidate a putative interaction between insulin and melatonin in diabetic patients and a diabetic rat model. We ...

journal_title：Journal of pineal research

authors： Peschke E,Frese T,Chankiewitz E,Peschke D,Preiss U,Schneyer U,Spessert R,Mühlbauer E

更新日期：2006-03-01 00:00:00

abstract：:The circadian system comprises several peripheral oscillators and a central rhythm generator that, in mammals, is located in the suprachiasmatic nucleus of the hypothalamus. Expression of clock genes is a characteristic feature of the central rhythm generator and the peripheral oscillators. With regard to the rhythmic...

journal_title：Journal of pineal research

authors： Torres-Farfan C,Serón-Ferré M,Dinet V,Korf HW

更新日期：2006-01-01 00:00:00

abstract：:We examined the effects of a single 2.5-mg dose of melatonin on the thermoregulatory and circulatory responses to intermittent exercise at a room temperature of 27.2+/-0.4 degrees C (mean+/-S.D.), a relative humidity of 55+/-3% (mean+/-S.D.), and a light intensity of 200-300 lux. In a double-blind cross-over study, si...

journal_title：Journal of pineal research

authors： Atkinson G,Holder A,Robertson C,Gant N,Drust B,Reilly T,Waterhouse J

更新日期：2005-11-01 00:00:00

abstract：:Improved survival because of advances in neonatal care has resulted in an increased number of infants at risk for chronic lung disease. Even though the etiology of lung injury is multifactorial, recent animal and clinical data indicate that pulmonary damage depends in large part on the ventilatory strategies used. Ven...

journal_title：Journal of pineal research

authors： Gitto E,Reiter RJ,Sabatino G,Buonocore G,Romeo C,Gitto P,Buggé C,Trimarchi G,Barberi I

更新日期：2005-10-01 00:00:00

abstract：:Maternal hyperthermia induces early embryonic death via increased oxidative stress to the embryo. In this study, we examined whether melatonin administered to heat-stressed pregnant mice would reduce hyperthermia-induced embryonic death. Mice were heat stressed (12 hr at 35 degrees C, 60% relative humidity) on the day...

journal_title：Journal of pineal research

authors： Matsuzuka T,Sakamoto N,Ozawa M,Ushitani A,Hirabayashi M,Kanai Y

更新日期：2005-10-01 00:00:00

abstract：:This study aimed to elucidate whether melatonin would exert beneficial effects on the neuronal functions of the nodose ganglion (NG) following acute hypoxic insult. The cytochrome oxidase (COX) and the nicotinamine adenine dinucleotide phosphate diaphorase (NADPH-d) histochemistry along with the nitric oxide synthase ...

journal_title：Journal of pineal research

authors： Chang HM,Tseng CY,Wei IH,Lue JH,Wen CY,Shieh JY

更新日期：2005-09-01 00:00:00

abstract：:In a recent study melatonin (N-acetyl-5-methoxytryptamine), a well-investigated animal molecule but minimally studied in plants, was seen to have a physiological role as growth-promoting molecule in lupin hypocotyls. In the present study, the role of melatonin as a growth promoter is extended to coleoptiles of canary ...

journal_title：Journal of pineal research

authors： Hernández-Ruiz J,Cano A,Arnao MB

更新日期：2005-09-01 00:00:00

abstract：:Although there is an increasing evidence that the pineal gland may play a role in human malignancy, the studies on melatonin concentrations in different types of malignant tumors brought about controversial results. However, changes in melatonin concentrations have been observed in some types of human malignant tumors...

journal_title：Journal of pineal research

authors： Karasek M,Kowalski AJ,Suzin J,Zylinska K,Swietoslawski J

更新日期：2005-08-01 00:00:00

abstract：:Aging induces changes in several organs and tissues, such as the liver, and this process might be due to oxidative damage caused by free radicals and inflammatory mediators. Melatonin is a secretory product with well-known antioxidant properties. The aim of this study was to investigate the effect of melatonin adminis...

journal_title：Journal of pineal research

authors： Castillo C,Salazar V,Ariznavarreta C,Vara E,Tresguerres JA

更新日期：2005-05-01 00:00:00

abstract：:In chronically inflamed animals, adrenal hormones exert a positive control on the secretion of melatonin by the pineal gland. In this paper, the mechanism of corticosterone as a modulator of melatonin and N-acetylserotonin (NAS) was determined. Rat pineal glands in culture, stimulated for 5 hr with noradrenaline (10 n...

journal_title：Journal of pineal research

authors： Ferreira ZS,Fernandes PA,Duma D,Assreuy J,Avellar MC,Markus RP

更新日期：2005-04-01 00:00:00

abstract：:Melatonin has previously been shown to be neuroprotective in rodent models of ischemic stroke. Herein, we tested whether this antioxidant may also be suitable for prophylactic use against stroke. To clarify this issue, melatonin was administrated orally for 9 wk (4 mg/kg/day) in mice and its effects on subsequent inju...

journal_title：Journal of pineal research

authors： Kilic E,Kilic U,Reiter RJ,Bassetti CL,Hermann DM

更新日期：2004-11-01 00:00:00

abstract：:Melatonin, an antioxidant, protects the pancreas against acute inflammation but, although this indole is released mainly at night, no study has been undertaken to determine circadian changes of plasma melatonin levels and the severity of acute pancreatitis. The aims of this study were: (a) to compare the severity of c...

journal_title：Journal of pineal research

authors： Jaworek J,Konturek SJ,Tomaszewska R,Leja-Szpak A,Bonior J,Nawrot K,Palonek M,Stachura J,Pawlik WW

更新日期：2004-10-01 00:00:00

abstract：:We investigated the role of melatonin on water avoidance stress (WAS)-induced degeneration of the gastric, ileal and colonic mucosa. Wistar albino rats were exposed to acute WAS (aWAS group) or chronic WAS (cWAS group). Before exposing animals to acute (aWAS + mel group) or chronic WAS (cWAS + mel group), 10 mg/kg mel...

journal_title：Journal of pineal research

authors： Ercan F,Cetinel S,Contuk G,Cikler E,Sener G

更新日期：2004-09-01 00:00:00

abstract：:Melatonin secretion is an endogenous synchronizer, and it may possess some anti-aging properties. Thus we examined melatonin levels in physiological aging, in extreme senescence and in senile dementia. In healthy old (age 66-94 yr) and young subjects (age 23-39 yr) and in demented patients (age 68-91 yr) plasma melato...

journal_title：Journal of pineal research

authors： Magri F,Sarra S,Cinchetti W,Guazzoni V,Fioravanti M,Cravello L,Ferrari E

更新日期：2004-05-01 00:00:00

abstract：:In healthy young men, administration of a single light pulse (5000 lux for 3 hr) or a single melatonin pill (5 mg) at 20:40 hr under controlled constant routine conditions of <10 lux, yielded a phase delay and a phase advance, respectively, in the circadian marker of dim light melatonin onset 24 hr later. Phase shifts...

journal_title：Journal of pineal research

authors： Wirz-Justice A,Kräuchi K,Cajochen C,Danilenko KV,Renz C,Weber JM

更新日期：2004-04-01 00:00:00

abstract：:The known neuroprotective actions of melatonin could be due to its antioxidant or radical scavenging activity, or they could be due to specific interactions of the indole with its receptors. A study of structure-activity relationships may provide useful information when a validated macromolecular target has not been (...

journal_title：Journal of pineal research

authors： Mor M,Silva C,Vacondio F,Plazzi PV,Bertoni S,Spadoni G,Diamantini G,Bedini A,Tarzia G,Zusso M,Franceschini D,Giusti P

更新日期：2004-03-01 00:00:00

abstract：:Respiratory activity is under circadian modulation and the physiological mechanisms may involve the pineal secretory product, melatonin, and the carotid chemoreceptor. We hypothesized that melatonin modulates the carotid chemoreceptor response to hypercapnic acidosis. To determine whether the effect of melatonin on th...

journal_title：Journal of pineal research

authors： Tjong YW,Chen Y,Liong EC,Ip SF,Tipoe GL,Fung ML

更新日期：2004-01-01 00:00:00

abstract：:We previously reported that pharmacological melatonin administration to type 2 diabetic rats reduces hyperinsulinemia and improves the altered fatty-acid metabolism. To determine whether melatonin deficiency exacerbates diabetes-associated conditions, we investigated the effect of pinealectomy (i.e. melatonin-deficien...

journal_title：Journal of pineal research

authors： Nishida S,Sato R,Murai I,Nakagawa S

更新日期：2003-11-01 00:00:00

abstract：:Previous studies have identified and characterized D1- and D2-dopamine receptors in bovine pineal glands. The data indicate that the density of D1-dopamine receptors (974 fmol/mg protein) far exceed that of D2-dopamine receptors (37 fmol/mg protein). The objective of this study was to identify the mRNAs for both D1- a...

journal_title：Journal of pineal research

authors： Santanavanich C,Chetsawang B,Ebadi M,Govitrapong P

更新日期：2003-10-01 00:00:00

abstract：:It is well established that some agents such as aminoglycosides generate free oxygen radicals, leading to an increased oxireductase production, which in turn increases tissue toxicity. The aim of this study is to test whether melatonin, the chief secretory product of the pineal gland and a highly effective antioxidant...

journal_title：Journal of pineal research

authors： Parlakpinar H,Ozer MK,Sahna E,Vardi N,Cigremis Y,Acet A

更新日期：2003-09-01 00:00:00

abstract：:Recently, a species-dependent distribution of melatonin binding sites have been found in lamina I-V and lamina X of the spinal cord. In order to learn more about the function of spinal melatonin receptors, we investigated (i) the gene expression for melatonin receptor subtypes in lumbar and thoracal spinal cord tissue...

journal_title：Journal of pineal research

authors： Zahn PK,Lansmann T,Berger E,Speckmann EJ,Musshoff U

更新日期：2003-08-01 00:00:00

abstract：:Antioxidant activity of a molecule is attributed to various mechanisms such as prevention of chain initiation, binding of transition metal ion catalysts and decomposition of peroxides. This study was aimed at evaluating the metal chelating and hydrogen peroxide (H2O2) scavenging activity of melatonin. The metal chelat...

journal_title：Journal of pineal research

authors： Gulcin I,Buyukokuroglu ME,Kufrevioglu OI

更新日期：2003-05-01 00:00:00

abstract：:In the present paper, binding of melatonin to purified cell nuclei from harderian glands of male and female hamsters was assessed. Binding of 125I-melatonin to cell nuclei fulfills the criteria for binding to a receptor site. Binding kinetics exhibit properties such as dependence on time and temperature as well as rev...

journal_title：Journal of pineal research

authors： Coto-Montes A,Tomás-Zapico C,Escames G,León J,Tolivia D,JosefaRodríguez-Colunga M,Acuña-Castroviejo D

更新日期：2003-04-01 00:00:00

abstract：:The antioxidant and anti-inflammatory effects of melatonin on kainic acid (KA)-induced neurodegeneration in the hippocampus were evaluated in vivo. It has been suggested that the pineal secretory product, melatonin, protects neurons in vitro from excitotoxicity mediated by kainate-sensitive glutamate receptors, and fr...

journal_title：Journal of pineal research

authors： Chung SY,Han SH

更新日期：2003-03-01 00:00:00

abstract：:Melatonin, the main secretory product of the pineal gland, has been shown to be potentially effective in prevention of numerous types of neurodegenerative disorders in which free radical processes are involved. Homocysteine (Hcy), an independent risk factor for atherosclerosis, undergoes auto-oxidation and generates r...

journal_title：Journal of pineal research

authors： Baydas G,Kutlu S,Naziroglu M,Canpolat S,Sandal S,Ozcan M,Kelestimur H

更新日期：2003-01-01 00:00:00